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Conclusion The possibility of an opioid mechanism underlying the antidepressant mechanisms of ketamine has been a recent subject of considerable debate

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Patients should be educated about red flag symptoms requiring immediate medical attention, including severe persistent abdominal pain (especially if radiating to the back, suggesting possible pancreatitis), right upper quadrant pain with fever or jaundice (potential gallbladder disease), inability to keep fluids down for more than 24 hours, syncope, chest pain, or difficulty breathing

M.NovakM.ThogersenH

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