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GHK-Cu occupies a more complex regulatory position: it is legally used as a cosmetic ingredient in topical formulations, but its use as an injectable compound for systemic effect is not approved and constitutes an unlicensed medicinal use

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Dysregulation of TNF alpha is involved in the pathogenesis of numerous inflammatory conditions, most notably rheumatoid arthritis, inflammatory bowel disease, psoriasis vulgaris, and psoriatic arthritis