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PMID: 34486734

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SFN promotes the phosphorylative degradation of -catenin while concurrently suppressing downstream targets including c-Myc and cyclin D1, effectively dismantling the transcriptional program that drives CSC self-renewal (71)

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

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