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GLP-1+GIP dual-agonists - such as tirzepatide - add a second mechanism: mimicking GIP (glucose-dependent insulinotropic polypeptide), which targets additional hormonal pathways involved in appetite and blood sugar regulation
Body composition changes particularly fat loss and lean mass improvements typically become apparent over 812 weeks of consistent use, with continued progress through 6 months
Being informed and proactive about these risks is essential
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10.1155/2015/706416 J
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