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Solovyev et al., 2019)
5-Amino-1MQ inhibits the enzyme NNMT (nicotinamide N-methyltransferase), which is involved in NAD+ metabolism within fat cells
Maitake, pioppini, lions mane, porcini, shiitake, yellow oyster and grey oyster all have good glutathione content
Cystathionine gamma-lyase then produces cysteine, which can support glutathione, taurine, sulfate and hydrogen-sulfide metabolism
Combination approaches that couple GSH-triggered release with ferroptosis induction, immunotherapy, radiotherapy, or metabolic modulation represent promising strategies to overcome resistance Fig
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