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Also, intercurrent events were not taken into consideration, such as smoking cessation, which could have affected weight loss [45]

62.9% of people treated with Wegovy achieved resolution of steatohepatitis with no worsening of liver fibrosis compared to 34.3% treated with placebo

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The amine and carboxylic acid groups of carnitine are the key groups for OCTN2 to recognize it, and the hydroxyl group of carnitine is esterified by acyl derivatives and does not hinder the recognition effect of OCTN2, indicating that OCTN2 has high substrate diversity and adaptability and is able to process a variety of acylcarnitines [162]

Most side effects are transient and manageable via dose adjustment in research