When combined with escitalopram, there is a potential for: Additive sedation , which can impair concentration, coordination, and the ability to drive safely Increased anticholinergic burden , potentially causing dry mouth, urinary retention, blurred vision, and constipation The primary concerns with first-generation antihistamines are sedation and anticholinergic effects rather than QT prolongation at usual therapeutic doses
Park JH, Peyrin-Biroulet L, Eisenhut M, Shin JI
Hursel R, Viechtbauer W, Westerterp-Plantenga MS
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