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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

J Neurosci Res (2013) 91(4):56877

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6.2.1 Oxidative damage The accumulation of Hcy and MMA leads to oxidative stress, a critical factor in NO-induced neurotoxicity

J Clin Endocrinol Metab 99(10):37083717 Bektas Uysal H, Ayhan M (2016) Autoimmunity affects health-related quality of life in patients with Hashimotos thyroiditis