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Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia

Small changes in the time of administration relative to ischemia can shift PRPs effect from anti-apoptotic to apparently pro-inflammatory, as shown in models where PRP given before ischemia produced stronger protective outcomes than when applied at reperfusion 52

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The IP team files patent applications covering every commercially valuable product attribute as data is generated: formulation work during Phase 2, manufacturing process optimizations during scale-up, method-of-use patents as each new indication is clinically developed, and polymorph and solvate patents following crystallization studies

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