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In avascular tissue zones, HIF-1 is stabilised (it is normally rapidly degraded under normoxic conditions by prolyl hydroxylase enzymes) and drives the transcription of dozens of hypoxia-response genes, including VEGF, erythropoietin, glucose transporters, and several matrix metalloproteinases involved in remodelling
Yet this compelling mechanistic story has generated precisely zero human clinical trials for mental health applications
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The liver protects itself from harmful oxidative reactions by producing glutathione inside its cells
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