405 Most patients with severe thalassemia experience complications of iron overload due to blood transfusions, which promote oxidative damage to various organs, leading to endocrine and ultimately organ dysfunction
Additionally, the anti-diabetic cognitive dysfunction effect of DAP was accompanied by the inhibition of inflammation and oxidative stress
Subsequently, in the large randomised placebo-controlled FIDELIO-DKD trial including adults with type 2 diabetes and CKD, finerenone reduced the risk of the primary kidney outcome (a composite of kidney failure, sustained eGFR decline 40% or kidney death) by ~20% [69]
It is a naturally occurring copper peptide complex studied for extracellular matrix remodeling, collagen-related signaling, wound-healing models, and skin-aging research
Long-term safety data in diverse populations are not yet available