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showed that NG-nitro-Larginine methyl ester treatment inhibits endothelial NOS (eNOS) abolished GLP-1 mediated vasorelaxation of rat pulmonary arteries [72]

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11 This section provides an overview of clinical trials investigating GLP-1RAs, dual GLP-1/GIP agonists, and triple GLP-1/GIP/glucagon agonists, with an emphasis on their efficacy, safety, and long-term implications