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Engs work sat largely dormant for nearly a decade, until animal studies around 1999 showed the lizard peptide improved glucose tolerance, expanded beta cell mass, and reduced food intake in rodents

8 Participants not using CPAP were enrolled in trial 1 (234 participants), and those using CPAP were enrolled in trial 2 (235 participants)

Glucagon adds a third mechanism: increased energy expenditure through hepatic lipid oxidation and thermogenesis