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This seemingly minor change -- the addition of a single methyl group -- can influence copper binding geometry, peptide stability, skin penetration, and biological activity

Homologues of human macrophage migration inhibitory factor from a parasitic nematode: gene cloning, protein activity and crystal structure

[1] Whilst vitamin B12 deficiency can cause serious health consequences including megaloblastic anaemia and neurological damage, supplementation is generally considered safe

Using them in various doses, which have not been refined or defined leaves our bodies to determine the benefits and the risks