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Re-authorization usually requires demonstrating 5% weight loss or continued progress

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Nat Commun 10(1):498 Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD (2020) Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis

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The activated macrophages release TNF-, which directs granuloma formation

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Steiner ME, Ness PM, Assmann SF, Triulzi DJ, Sloan SR, Delaney M, et al

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