The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation
Those results dwarf what any single peptide, supplement, or lifestyle modification achieves in isolation
this list is not exhaustive Antacids Colchicine (treatment of gout) H2 Blockers (Zantac, Tagamet, Pepcid) Metformin Diabetes drug (Glucophage) PPIs Proton pump inhibitors (Omeprazole, Nexium, Prevacid, Protonix) Nitrous oxide anaesthesia Nitrous oxide recreational abuse (Laughing gas / Whippets / Hippy crack) Mycifradin sulphate (Neomycin) antibiotic Para aminosalicylates antibiotic Phenytoin (Dilantin) anti-epileptic Potassium chloride (K-Dur) Cholestyramine (Questran) Chemotherapy and radiation treatment Increased demands Chronic Hemoltic anaemia Hyperthroidism Multiple myeloma Myelopproliferative disorders Neoplasms Pregnancy Some patients may never find out the cause of their condition, this does not mean that they should be denied B12 injections which are, safe, inexpensive and the most efficient treatment for their deficiency
Use 1 to 2% concentrations rather than chasing the highest number
Unlike Hydroxocobalamin, Cyanocobalamin is a synthetic version that can be purchased over the counter at your local pharmacy, grocery store, or health food shop