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Most PD-associated LRRK2 mutations represent gain-of-function alleles: the G2019S and I2020T in the kinase domain cause hyper-phosphorylation of Rabs (West et al., 2005
RF microneedling uses a device that does a little bit of multitasking: it sends radiofrequency energy into your skin while also giving it tiny needle pricks
Proper storage and handling are to maintain the efficacy and integrity of these research-grade peptides
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You can't just copy a protocol off the internet and call it a day
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