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The SURMOUNT-1 trial initially found that patients with obesity taking tirzepatide for 72 weeks lost 15% to 22.5% of their initial weight, on average, depending on the dose, and also saw a significant average reduction in their levels of glycated hemoglobin, known as A1c levels, a standard measure of blood sugar control
Plotting the fluorescence intensity ratios with excitation wavelengths at 405 and 488 nm (F 405 /F 488 ) as a function of GSH concentrations confers a superb linear relationship ( R 2 =0.998) covering the physiological GSH concentration range 110 mM (Fig
