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Linking the two drugs had a synergistic effect in obese mice, prompting significantly more weight loss than either drug delivered alone and reducing insulin, cholesterol, and triglyceride concentrations in plasma
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GLP-1 drugs may be prescribed for the following conditions as per American Diabetes Association/European Association for the Study of Diabetes (ADA/EASD) 2025 guidelines 11 : Primary glycaemic indication: GLP-1 RAs are recommended for adults with type 2 diabetes who have not reached their individualised A1C targets (typically when A1C is 1.5% above the agreed glycaemic goal) despite lifestyle measures and foundational therapy such as metformin
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