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Correlation analysis between metagenome and metabolome For the microbial diversity analysis, R statistical software (version 3.6.3) was utilized

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After a three-day induction phase (consisting of low-carbohydrate meals and broth), SL completed 21 consecutive days of water-only intake under close inpatient monitoring

The metabolitemetabolite partial correlations that were of differential strength between networks of high and low HRSD 17 networks were further validated for significant interaction effects through linear regression analysis