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This translated into a significantly higher likelihood of achieving the conventional glycemic target of HbA1c 30, those randomized to tirzepatide experienced 36 adjudicated cardiovascular deaths or heart failure worsening events versus 56 in the placebo group, representing a 38% reduction primarily driven by fewer heart failure exacerbations
Mechanism 2
The research showing benefits used concentrations as low as 0.01 nM
Characterization of microsomal glutathione S-transferases MGST1, MGST2, and MGST3 in cynomolgus macaque
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