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Acidic pH impairs the activity of the mitochondrial L-2-HG removal enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) and enhances the protein stabilization of HIF-1, leading to its escape from the degradation pathway 90

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214 Clinically, SGLT2 inhibitors have demonstrated significant benefits in patients with HF, regardless of ejection fraction, 215,216,217,218 and SGLT2 inhibitors are also safe and effective in AMI patients