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Released rapidly in response to nutrient ingestion, especially carbohydrates and fats, it enhances insulin secretion from pancreatic beta cells in a glucose-dependent manner, effectively lowering postprandial blood glucose without risking hypoglycemia

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Those without a uterus are the only ones who can be safely prescribed an estrogen-only regimen.5 And if the potential side effects of HRT concern you, transdermal application (topical) may reduce some of the risks particularly the chance of blood clots