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mtDNA mutations are implicated in various disorders, including mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), maternally inherited Leigh syndrome (MILS), myoclonic epilepsy with ragged red fibers (MERRF), Lebers hereditary optic neuropathy (LHON), Kearns-Sayre syndrome, Pearson syndrome, and chronic progressive external ophthalmoplegia (CPEO)