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Authors : Willard FS, Douros JD, Showalter AD, Wainscott DB, Suter TM, Capozzi ME, Cardona GR, Urva S, Emmerson PJ, Rosenkilde MM, Campbell JE, Sloop KW Source : Studies of the dual GIP and GLP-1 receptor agonist tirzepatide reveal occupancy favoring the GIP receptor and biased cAMP signaling at the GLP-1 receptor

Whilst heartburn or reflux were not consistently itemised as standalone symptoms in trial reporting, nausea, vomiting, and upper abdominal discomfort symptoms that frequently co-exist with reflux were consistently noted

Tirzepatide works by activating both GIP and GLP-1 receptors