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[PubMed ID: 17565645].

Signs suggesting cycle extension include continued gradual improvement at cycle end, incomplete resolution of primary concerns, and recent flare or setback

For example, overexpression of VvMYB5b increases anthocyanin and proanthocyanidins accumulation but also alters broader phenylpropanoid metabolism and developmental processes (Deluc et al., 2008)

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Their favorable bioactivity profile, combined with high tissue penetration and low immunogenicity, supports their integration into advanced delivery platforms such as hydrogels or topical formulations [14, 29]