glp 1 and dopamine GLP-1 Receptor Signaling Mechanisms in Reward Circuits. GLP-1R Use of Glucagon-Like Peptide-1 |

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During meals, GLP-1 is secreted in two stages: a first peak occurs approximately 15 min after the beginning of the meal, when food in the stomach and in the initial portions of the intestine stimulates the release of hormones, such as glucose-dependent insulinotropic polypeptide (GIP), which acts by vagal pathways to stimulate L cells [12]

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It also maintains the vascular tone by enhancing the levels of endothelial nitric oxide (NO)