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Development of antiobesity medication has not been easy, because of unexpected adverse events

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These can irritate the sensitive skin around the anus, making hemorrhoids more painful

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A 300-pound person loses a higher absolute amount of weight (24% of 300 pounds = 72 pounds) than a 200-pound person (24% of 200 pounds = 48 pounds) on the same dose, because there is simply more metabolically active tissue responding to the signal