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Impaired activity of methionine synthase results in elevated blood concentrations of homocysteine, while impaired activity of L-methylmalonyl-CoA mutase results in increased concentrations of a metabolite of methylmalonyl-CoA called methylmalonic acid (MMA) in blood and urine
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Unexplained elevations above 1,000 pg/mL warrant further investigation, not panic, but not dismissal either
Possible known side effects of Saphnelo include: headache nausea vomiting fatigue increased risk for infections (Do not take this medication if you have a current infection.) hypersensitivity to the medication Learn more information about the SLE Workshop at HSS, a free support and education group held monthly for people with lupus and their families and friends.
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