The novel uricosurics agent including lesinurad, arhalofenate, canagliflozin, xanthine oxidase inhibitor tetrapeptide EEAK, rhodiola crenulata, favipiravir, PF-06743649 increase renal urate excretion by inhibiting reabsorption
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According to the National Institute on Drug Abuse (NIDA), individuals dependent on these medications may experience cravings, mood swings, and physical withdrawal symptoms such as nausea, sweating, and muscle pain when not taking the drug
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The etiology and/or the exact cause of UF are still unclear