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The rise of glucagon-like peptide-1 receptor agonists (GLP-1 RA) drugs has transformed the healthcare landscape, capturing widespread attention and adoption
Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome
Show Sources Photo Credit: Moment/Getty Images SOURCES: Cleveland Clinic: GLP-1 Agonists, Dehydration, Ozempic Face: What It Is and How To Avoid It, Elastin, Sebaceous Glands, Telogen Effluvium, Can Ozempic Cause Hair Loss? What the SPF in Your Sunscreen Means, Best Ingredients and Products for Your Anti-Aging Skin Care Routine, Subcutaneous Fat. Clinical, Cosmetic and Investigational Dermatology: Dietary water affects human skin hydration and biomechanics. NIH Diseases: A Closer Look at the Dermatological Profile of GLP-1 Agonists. NIH Endocrine: GLP-1RA and the possible skin aging. George Washington University: Media Tip Sheet: The Impact GLP-1 Drugs Have on Your Skin, Study Links Popular GLP-1 Weight-Loss Drugs to Increased Risk of Hair Loss. UCLA Health: Ozempic face (and other GLP-1 side effects). Journal of Clinical and Aesthetic Dermatology: A Review of Glucagon-like Peptide-1 in Dermatology. Harvard Health: GLP-1 diabetes and weight-loss drug side effects: Ozempic face and more. JAMA Internal Medicine Patient Page: I Am Taking a GLP-1 Weight-Loss MedicationWhat Should I Know? American Journal of Physiology Regulatory, Integrative and Comparative Physiology: Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. Mayo Clinic: Psoriasis. Journal of Cellular Signaling: A Discussion on the Relationship between Skin Lipid Metabolism and Whole-Body Glucose and Lipid Metabolism: Systematic Review. Cureus: Hair Loss Associated With Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Use: A Systematic Review. JAAD International: Increased Incidence and Risk of Hair Loss with GLP-1 Receptor Agonists: A RealWorld Multicenter TrinetX Cohort Study. American Academy of Dermatology Association: "Dermatologists' Top Tips for Relieving Dry Skin.
The researchers also found reduced responses to GLP-1 in both the pancreas and the gut, even though the number of GLP-1 receptors in these tissues remained unchanged
Mechanism of Action The mechanism involves PT-141 acting as a non-selective agonist of the melanocortin receptors, with a high affinity for MC3R and MC4R in the brain
