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28 The efficacy of these approaches has been demonstrated in multiple trials and confirmed by meta-analyses

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Metabolites were resolved across a 2.1 150 mm, 1.7 m Kinetex C18 column (Phenomenex) using a 5-min, reverse-phase gradient from a previously described method 19

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Warburg-like effect and lactate accumulation Lactate is the end product of anaerobic glycolysis, which is produced by the nicotinamide adenine dinucleotide-dependent reduction of pyruvate catalyzed by lactate dehydrogenase-A (LDHA) [112]

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