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Observational studies A large number of cross-sectional and prospective cohort studies have associated elevated blood homocysteine concentrations with measures of poor cognitive scores and increased risk of dementia, including Alzheimer's disease (reviewed in 67, 69)

A threshold that doesn't trigger clinical deficiency symptoms but correlates with persistent fatigue, brain fog, and impaired fat metabolism

However, neurologically significant deficiency may occur with low-"normal" serum levels

Remove that consistency and your results become unreliable, your side effect profile changes, and your ability to make informed decisions about dose adjustments disappears