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Overall, strategies aimed at improving dopamine function are encouraged for the treatment and prevention of obesity, which can be seen as a type of reward deficiency
Targeting this axis may therefore represent a promising strategy to normalize TRP-KYN balance and mitigate depressive symptom burden in MDD
The PtdIns-4-P can then be further phosphorylated by both PI3K and phosphatidylinositol-4-phosphate 5-kinases (PIP5K) which generates PtdIns-3,4-P 2 or PtdIns-4,5-P 2 , respectively
Curr Diab Rep 15(6):36
However, one of the most important limitations is heterogeneity of the study populations, including disease type, tolerance to treatment, dose of DHA and EPA, timing and duration of DHA and EPA supply, EPA to DHA ratio, initial EPA and DHA status, intake of other nutrients such as vitamins, clinical status, and concomitant use with medications
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