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The relationships of the metabolic pathways are illustrated in Fig

Ensuring Healthy Weight Loss The researchers ultimately conclude that GLP-1 drugs significantly reduce body weight and adiposity, along with a substantial FFM [fat-free mass] loss, but with no clear evidence of CRF enhancement. They remain concerned that this could take a toll on patients metabolic health, healthspan/frailty and overall longevity

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Fatty acids and energy needs: Fatty acids are used in the mitochondria to produce energy when glucose isnt available