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A mechanistic study published in 2025 traced these changes substantially to a glucagon-driven reduction in a liver protein complex (ANGPTL3/8) that controls how the bloodstream clears triglycerides, a pathway most other cholesterol drugs do not target directly [10]
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METFORMIN Metformin is a hypoglycemic agent that acts by activating AMPK in cells and reducing glucose production in the liver 50
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