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95% CI, 1-1.28) occurred more often in women at high risk for developing breast cancer who received 5 years of tamoxifen therapy (n = 6681) compared with placebo (n = 6707)

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More specifically, the ARC nucleus of the hypothalamus has been highlighted as one of the main sites mediating this action as chemical lesion of the ARC in rats ablates the anorectic action of GLP-1 (Tang-Christensen et al., 1998)

Further optimization led to once-weekly administration instead of daily administration, longer-lasting presence in plasma (blood), superior target outcomes (i.e

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