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Ethics approval and consent to participate Ethical review was not required because the study is a review of literature

Arginine is crucial for producing nitric oxide, which helps relax blood vessels, improve blood flow, and support muscle development

Insulin and several other everyday medicines are given the same way

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved

The following points highlight the positive outcomes associated with GH increase in adults: [*] Body Composition Improvement: GH replacement therapy induces an increase in lean body mass and a decrease in fat mass