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Semaglutide also has the added benefit of supporting weight loss, which is a significant advantage for people with type 2 diabetes who are overweight
While constipation is common with GLP-1 agonists, it should respond to standard remedies
It will, as a result, cover the expensive downstream sequelae of a disease while excluding treatment of the disease itself
Sample size was determined based on practical considerations, prior experience with similar phase 1 study designs, and the objective of obtaining sufficient safety and pharmacokinetic data to support dose escalation decisions
3c and supplementary Fig
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