Questions to Ask About Evidence Quality and Safety Readers can ask a licensed clinician whether the claim is based on topical human data, wound-care research, animal models, cell studies, cosmetic marketing, or unsourced online protocols
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The M1 phenotype is often associated with disease, resulting in production and secretion of pro-inflammatory cytokines (i.e., tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), and IL-6), chemokines, and ROS to neutralize pathogens and increase cell recruitment to the site of inflammation
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Costa-Borges N, Spath K, Miguel-Escalada I et al