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Thats of course the million-dollar question, and the answer isnt fully understood

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[4] In other words, most patients with detectable anti-sermorelin antibodies continue to respond to therapy, and the antibodies may disappear over time even if treatment continues

The gold standard involves HPLC (High-Performance Liquid Chromatography) testing combined with mass spectrometry, conducted by an independent laboratory with no financial ties to the vendor