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Factors Indicating Against Dose Escalation Maintain current dose when experiencing significant side effects at present level, achieving satisfactory subjective improvements (better sleep, energy, recovery), IGF-1 increased adequately (50+ ng/mL) for optimization goals, or financial constraints make higher dosing unsustainable

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DOI: 10.3390/ijms22136719 [Google Scholar] Philp AM, Collier RL, Grover LM, Davis ET, Jones SW

Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the MGF E peptide actions in vitro