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Laboratory studies explore optimal administration regimens for different research objectives, including acute versus chronic senescent cell elimination and the effects of repeated administrations on tissue function and aging markers
No serious adverse events have been reported across extensive research use
Any disruption along this pathway can lead to deficiency regardless of dietary intake, which is why some patients need supplementation even when they eat B12-rich foods
These reactions are typically short-lived and resolve without intervention
All animals were bred in the pathogen-free facility with a 12 h light/dark cycle at temperature (2025 C), relative humidity (4060%), and had ad libitum access to food and water
