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Detection methods can identify the peptide and its metabolites in both blood and urine

Mitochondria are important components of cell metabolism, and the changes in mitochondrial outer membrane permeability are closely related to apoptosis

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Since D2HG and L2HG are indistinguishable in standard LC-MS, to determine which 2HG enantiomer(s) is affected, we adapted a chiral N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) derivation followed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis 24,40

In Vitro Cell Model Systems Myocyte Cell Culture Models Primary myocyte cultures and established myoblast cell lines serve as standard experimental models for IGF-1 LR3 receptor pharmacology studies