May SA, Johnson MD, Buser JY, Campbell AN, Frank SA, Haeberle BD, Hoffman PC, Lambertus GR, McFarland AD, Moher ED, White TD, Declan Hurley D, Corrigan AP, Gowran O, Kerrigan NG, Kissane MG, Lynch RR, Sheehan P, Spencer RD, Pulley SR
Firstly, hyperglycemia promotes local ANG II production in cardiomyocytes stimulating intracellular chymase and/or internalized prorenin, leading to diabetic cardiomyopathy
They want the reassurance that comes from years of rigorous observation
Short-term weight increases during retatrutide treatment are most commonly caused by fluid retention, constipation, normal daily weight fluctuation, or inadequate appetite suppression during early dose titration not necessarily treatment failure
Depends entirely on whether you follow a systematic nutrition strategy or wing it