B.NajarT.GhramA.DabbebiH.Ben MradM.AbdrabbahM
10.3390/ijms17030367 5
Furthermore, the distribution of these developability metrics across design rounds (Supp Figure 1) demonstrated that the iterative optimization process maintained favorable biophysical properties, with round 4 candidates showing balanced pI values (68), high humanization scores (Hu 0.7), and consistently low risk scores for aggregation, viscosity, and non-specific binding
However, the test subjects did experience the following minor side effects: Mild injection site reactions (pain, itching, swelling) Headaches Diarrhea, Hypertension Induration CJC-1295 administration has also been linked to mild, transitory side effects such as flushing, water retention, and insomnia [7]
Computational bioprospecting Guggulsterone against ADP ribose phosphatase of SARS-CoV-2