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NICE guidelines suggest reassessing after 6 months, with continued prescription only if youve lost at least 5% of your starting weight
The broader question of how long semaglutide remains viable depends on storage conditions, reconstitution method, and handling practices
Specific concerns for athletes include: Dehydration risk: Gastrointestinal side effects combined with intense exercise and sweating may increase dehydration risk, potentially leading to acute kidney injury in severe cases Hypoglycaemia: Although less common without concomitant insulin or sulfonylurea use, low blood glucose can impair training performance and cognitive function Fatigue and reduced exercise capacity: Some users report decreased energy levels, which may compromise training intensity and volume Tachycardia: Tirzepatide can cause modest increases in heart rate, which may be additive to exercise-induced elevations Gallbladder disease: Increased risk of gallstones and cholecystitis, particularly with rapid weight loss Pancreatitis: Rare but serious cases of acute pancreatitis have been reported
The studies are correlative, but appear to show that the drugs not only reverse the carcinogenic risks that come with obesity, they may also have additional anti-inflammatory effects that help suppress tumors
Wandt, V
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