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Injecting too fast forces a large bolus of liquid into a small subcutaneous space, which can cause pain, lump formation, and potentially altered absorption kinetics
Restless Legs Syndrome is not life-threatening , but untreated symptoms can be serious enough to cause chronic sleep deprivation, impaired concentration, mood disturbances, and reduced quality of life
Furthermore, DKD is an established risk factor for cardiovascular disease (CVD) (Rawshani et al., 2018)
Prolonged selenium deficiency may likely contribute to Keshan and Kashin-Beck diseases (see below)
Whilst one phase III trial did not reveal a significant difference in ALSFRS-R score when additional patient inclusion criteria were applied [Oakes et al., 2017
