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Mice were euthanized in a non-fasted state over 2 days during their sleep cycle
Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities
The same study used a euglycemic-clamp method and did not observe the adverse insulin-sensitivity effect associated with intact hGH under the compared experimental conditions
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