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Reported EC values for MT-II in transfected cell assays fall in the sub-nanomolar to low-nanomolar range at MC1R and MC4R, roughly an order of magnitude weaker at MC3R and MC5R, and it is essentially inactive at MC2R, the adrenocorticotropin receptor

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While emerging preclinical research suggests potential anti-inflammatory properties, there is currently no FDA-approved indication for GLP-1 medications in treating Crohn's disease or any inflammatory bowel disease

00:15:05 Don Weinberger: Thats definitely concerning